| Session 1. Micro/Nano-fluidics Technology of UK/KOREA |
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| Recent years have seen considerable progress in the development of microfabricated systems for use in the chemical and biological sciences. Much development has been driven by a need to perform rapid measurements on small sample volumes in areas such as chemical synthesis, DNA/Protein analysis, drug discovery, pharmaceutical screening, proteomics and medical diagnostics. However, at a more primary level, interest in miniaturized analytical systems has been stimulated by the fact that physical processes can be more easily controlled and harnessed when instrumental dimensions are reduced to the micrometre scale. For example, it is well recognized that when compared to macroscale instruments, micro/nano-fluidic systems engender a number of distinct advantages with respect to speed, analytical throughput, reagent usage, process control, automation and operational and configurational flexibility. In general terms, such systems define new operational paradigms and provide predictions about how molecular synthesis and analysis might be revolutionized in the coming years. This session will introduce some of the key features and benefits of micro/nano-fluidic systems and describe the use of such devices for performing ultra-fast biological and chemical analysis. Specifically, the following areas will be highlighted with respect to relevant chemical and biological applications. In this session several approaches will be described regarding the development and application of nanofluidic devices for single molecule binding studies in UK and KOREA. |
| Chair : Soo-Ik CHANG, Professor, Chungbuk Nat'l Univ. |
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| - Microfluidic Approaches to Quantitative Point-of-Care Diagnostics |
| Andrew J. deMello, Professor of Chemical Nanosciences, Chemistry, Imperial College London |
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- Nano-bio and Systems-bio Platform Technologies for Diagnosis and
Therapy |
| Sang Yup LEE, Distinguished Professor, Chemical Engineering, Korea Advances Institute of Science and Tech. |
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| - Biological Experiments in Microfluidic Microdroplets |
| Florian HOLFELDER, Lecturer, Dept. of Biochemistry, Univ. of Cambridge |
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| - Highly Sensitive Biological Analysis Using Optical Microfluidic Sensor |
| Jaebum CHOO, Professor, Dept. of Applied Chemistry, Hanyang Univ. |
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| Session 2. Micro/Nano-biotechnology of UK/KOREA I |
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| Micro/nanobiotechnology is a rapidly advancing area of scientific and technological opportunity that applies the tools and processes of micro/nanofabrication to build devices for studying biosystems. Researchers learn from biology to create new micro-nanoscale devices to better understand life processes at the nanoscale. Micro/nanotechnology on a chip is a new paradigm for total biological analysis systems. The ability to make chemical or biological information easier and less costly to obtain will impact molecular binding analysis, diagnostics and high through screening for drugs. Some examples of devices are micro/nanofluidic chips and protein nanobiochips. These devices can be adapted for point-of-care use. One of the more promising uses of nanofluidic devices is isolation and analysis of individual biomolecules, such as protein or DNA. This capability could lead to new detection schemes for disease as a cancer. Protein microarrays for the study of protein function are not widely used, in part because of the challenges in producing proteins to spot on the arrays. In these sessions some of the key features and benefits of micro/nano-biotechnology systems and its fabrication & application for biological research will be presented. |
| Chair : Robin J. LEATHERBARROW, Head/Professor , Imperial College London |
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- High-throughput Screening of Antibody-mimic Peptides by
Using a Protein Microarray Chip |
| Soo-Ik CHANG, Professor, Dept. of Biochemistry, Chungbuk Nat’l Univ. |
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| - New Techniques in Electrochemistry : From Selectivity to Flow |
| Danny O'HARE, Reader, Bioengineering, Imperial College London |
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| - Biomedical Imaging and Therapy Using Nanomaterials |
| Bong Hyun CHUNG, Director, BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotech. |
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- Wireless Biosensor Devices
: Extending the Lab-on-a-Chip Concept into Smart Diagnostics |
| Jon M. COOPER, Professor, Bioengineering, Univ. of Glasgow |
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| Session 3. Micro/Nano-biotechnology of UK/KOREA II |
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| Micro/nanobiotechnology is a rapidly advancing area of scientific and technological opportunity that applies the tools and processes of micro/nanofabrication to build devices for studying biosystems. Researchers learn from biology to create new micro-nanoscale devices to better understand life processes at the nanoscale. Micro/nanotechnology on a chip is a new paradigm for total biological analysis systems. The ability to make chemical or biological information easier and less costly to obtain will impact molecular binding analysis, diagnostics and high through screening for drugs. Some examples of devices are micro/nanofluidic chips and protein nanobiochips. These devices can be adapted for point-of-care use. One of the more promising uses of nanofluidic devices is isolation and analysis of individual biomolecules, such as protein or DNA. This capability could lead to new detection schemes for disease as a cancer. Protein microarrays for the study of protein function are not widely used, in part because of the challenges in producing proteins to spot on the arrays. In these sessions some of the key features and benefits of micro/nano-biotechnology systems and its fabrication & application for biological research will be presented. |
Chair : Andrew J. deMello, Professor of Chemical Nanosciences, Chemistry, Imperial College London |
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- Recent Advance in ProteoChip Technology
Chip-based Profile Study of Differential Protein Experssion in Cells |
| In-Cheol KANG, Professor/Director, Dept. of Biological Science, Hoseo Univ. |
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- Biomolecules and Nanomaterials
: Engineering the Hard/Soft Interface |
| Tony CASS, Professor, Chemical Biology, Imperial College London |
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- Bioconjugation and Biofunctionality of Surface Immobilized Proteins
for Biochip Applications |
| Eun Kyu LEE, Director/Professor, Bionanotechnology BK21 Program/Dept. of Chemical Engineering, Hanyang Univ. |
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- Attachment of Chemical Labels to the N-terminus of Proteins by
Protease Digestion and Native Chemical Ligation |
| Robin J. LEATHERBARROW, Head/Professor, Biological and Biophysical Chemistry/Dept. of Chemistry, Imperial College London |
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